Phys. Rev. Lett. 100, 018105 (2008) [4 pages]Point-Mutation Effects on Charge-Transport Properties of the Tumor-Suppressor Gene p53Received 23 August 2007; published 8 January 2008 We report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective tight-binding models which simulate hole propagation along the DNA, a statistical analysis of mutation-induced charge transfer modifications is performed. In contrast to noncancerous mutations, mutation hot spots tend to result in significantly weaker changes of transmission properties. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis. © 2008 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.100.018105
DOI:
10.1103/PhysRevLett.100.018105
PACS:
87.15.A−, 87.14.G−, 87.19.xj
|
|
About | Terms and Conditions | Subscriptions | Search | Help
Use of the American Physical Society websites and journals implies that the user has read and agrees to our Terms and Conditions and any applicable Subscription Agreement. Physical Review®, Physical Review Letters®, Reviews of Modern Physics®, and Physical Review Special Topics® are trademarks of the American Physical Society.