Phys. Rev. Lett. 100, 180602 (2008) [4 pages]Optimized Free Energies from Bidirectional Single-Molecule Force SpectroscopyReceived 6 February 2008; published 6 May 2008 An optimized method for estimating path-ensemble averages using data from processes driven in opposite directions is presented. Based on this estimator, bidirectional expressions for reconstructing free energies and potentials of mean force from single-molecule force spectroscopy—valid for biasing potentials of arbitrary stiffness—are developed. Numerical simulations on a model potential indicate that these methods perform better than unidirectional strategies. © 2008 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.100.180602
DOI:
10.1103/PhysRevLett.100.180602
PACS:
05.70.Ln
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