Phys. Rev. Lett. 100, 228105 (2008) [4 pages]Nucleosome SwitchesReceived 7 August 2007; published 6 June 2008 We present a statistical-mechanical model for the positioning of nucleosomes along genomic DNA molecules as a function of the strength of the binding potential and the chemical potential of the nucleosomes. We show that a significant section of the DNA is composed of two-level nucleosome switching regions where the nucleosome distribution undergoes a localized, first-order transition. The location of the nucleosome switches shows a strong correlation with the location of gene-regulation regions. © 2008 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.100.228105
DOI:
10.1103/PhysRevLett.100.228105
PACS:
87.15.A−, 05.20.Jj, 87.16.Sr
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