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Phys. Rev. Lett. 101, 178101 (2008) [4 pages]

Origin of Contractile Force during Cell Division of Bacteria

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Biplab Ghosh1,2 and Anirban Sain1,*
1Physics Department, Indian Institute of Technology–Bombay, Powai, Mumbai, 400076, India
2Theoretical Physics Division, Bhabha Atomic Research Center, Trombay, Mumbai 400085, India

Received 17 October 2007; published 20 October 2008

When a bacterium divides, its cell wall at the division site grows radially inward like the shutter of a camera and guillotines the cell into two halves. The wall is pulled upon from inside by a polymeric ring, which itself shrinks in radius. The ring is made of an intracellular protein FtsZ (filamenting temperature sensitive Z) and thus is called the Z ring. It is not understood how the Z ring generates the required contractile force. We propose a theoretical model and simulate it to show how the natural curvature of the FtsZ filaments and lateral attraction among them may facilitate force generation.

© 2008 The American Physical Society

URL:
http://link.aps.org/doi/10.1103/PhysRevLett.101.178101
DOI:
10.1103/PhysRevLett.101.178101
PACS:
87.15.A−, 05.40.−a, 87.15.R−, 87.16.−b

*asain@phy.iitb.ac.in