Phys. Rev. Lett. 102, 018101 (2009) [4 pages]Three-Dimensional Visualization of a Human Chromosome Using Coherent X-Ray Diffraction
Coherent x-ray diffraction microscopy is a lensless phase-contrast imaging technique with high image contrast. Although electron tomography allows intensive study of the three-dimensional structure of cellular organelles, it has inherent difficulty with thick objects. X rays have the unique benefit of allowing noninvasive analysis of thicker objects and high spatial resolution. We observed an unstained human chromosome using coherent x-ray diffraction. The reconstructed images in two or three dimensions show an axial structure, which has not been observed under unstained conditions. © 2009 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.102.018101
DOI:
10.1103/PhysRevLett.102.018101
PACS:
87.59.−e, 42.30.Wb, 61.05.cp, 87.16.Sr
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