Phys. Rev. Lett. 102, 158104 (2009) [4 pages]Control of DNA Replication by Anomalous Reaction-Diffusion KineticsReceived 3 December 2008; published 16 April 2009 We propose a simple model for the control of DNA replication in which the rate of initiation of replication origins is controlled by protein-DNA interactions. Analyzing recent data from Xenopus frog embryos, we find that the initiation rate is reaction limited until nearly the end of replication, when it becomes diffusion limited. Initiation of origins is suppressed when the diffusion-limited search time dominates. To fit the experimental data, we find that the interaction between DNA and the rate-limiting protein must be subdiffusive. © 2009 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.102.158104
DOI:
10.1103/PhysRevLett.102.158104
PACS:
87.15.A−, 87.14.gk, 87.17.Ee
|
|
About | Terms and Conditions | Subscriptions | Search | Help
Use of the American Physical Society websites and journals implies that the user has read and agrees to our Terms and Conditions and any applicable Subscription Agreement. Physical Review®, Physical Review Letters®, Reviews of Modern Physics®, and Physical Review Special Topics® are trademarks of the American Physical Society.