Phys. Rev. Lett. 76, 2591–2594 (1996)Similarity Detection and LocalizationReceived 9 November 1995; published in the issue dated 1 April 1996 The detection of similarities between long DNA and protein sequences is studied using concepts of statistical physics. It is shown that mutual similarities can be detected by sequence alignment methods only if their amount exceeds a threshold value. The onset of detection is a critical phase transition viewed as a localization-delocalization transition. The fidelity of the alignment is the order parameter of that transition; it leads to criteria to select optimal alignment parameters. © 1996 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.76.2591
DOI:
10.1103/PhysRevLett.76.2591
PACS:
87.10.+e, 05.70.Jk, 74.60.Ge
|
|
About | Terms and Conditions | Subscriptions | Search | Help
Use of the American Physical Society websites and journals implies that the user has read and agrees to our Terms and Conditions and any applicable Subscription Agreement. Physical Review®, Physical Review Letters®, Reviews of Modern Physics®, and Physical Review Special Topics® are trademarks of the American Physical Society.