Phys. Rev. Lett. 77, 3565–3568 (1996)Freezing Transition of Compact PolyampholytesReceived 15 July 1996; published in the issue dated 21 October 1996 Polyampholytes (PAs) are heteropolymers with long range Coulomb interactions. Unlike polymers with short range forces, PA energy levels have nonvanishing correlations and are thus very different from the random energy model (REM). Nevertheless, if charges in the PA globule are screened as in a regular plasma, PAs freeze in REM fashion. Our results shed light on the potential role of Coulomb interactions in folding and evolution of proteins, which are weakly charged PAs, in particular, making connection with the finding that sequences of charged amino acids in proteins are not random. © 1996 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.77.3565
DOI:
10.1103/PhysRevLett.77.3565
PACS:
61.41.+e, 64.70.Dv
|
|
About | Terms and Conditions | Subscriptions | Search | Help
Use of the American Physical Society websites and journals implies that the user has read and agrees to our Terms and Conditions and any applicable Subscription Agreement. Physical Review®, Physical Review Letters®, Reviews of Modern Physics®, and Physical Review Special Topics® are trademarks of the American Physical Society.