Phys. Rev. Lett. 78, 4518–4521 (1997)

Dynamic Control of Cardiac Alternans

Abstract

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Kevin Hall¹, David J. Christini², Maurice Tremblay³, James J. Collins², Leon Glass¹, and Jacques Billette³
¹Departments of Physics and Physiology, McGill University, Montreal, Quebec, Canada
²Neuromuscular Research Center and Department of Biomedical Engineering, Boston University, Boston, Massachusetts
³Départment de Physiologie, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada

Received 17 December 1996; published in the issue dated 9 June 1997

A dynamic control technique was used to suppress a cardiac arrhythmia called an alternans rhythm in a piece of dissected rabbit heart. Our control algorithm adapted to drifting system parameters, making it well suited for the control of physiological rhythms. Control of cardiac alternans rhythms may have important clinical implications since they often precede serious cardiac arrhythmias and are a harbinger of sudden cardiac death.

URL:

http://link.aps.org/doi/10.1103/PhysRevLett.78.4518

DOI:

10.1103/PhysRevLett.78.4518

PACS:

87.22.-q, 05.45.+b, 07.05.Dz, 87.10.+e

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Phys. Rev. Lett. 78, 4518–4521 (1997)

Dynamic Control of Cardiac Alternans

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