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APS » Journals » Phys. Rev. Lett. » Volume 86 » Issue 7
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Phys. Rev. Lett. 86, 1378–1381 (2001)

Near-Field Scanner for Moving Molecules

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Jonas O. Tegenfeldt1, Olgica Bakajin1, Chia-Fu Chou1, Shirley S. Chan1, Robert Austin1, Wunshain Fann2, Lim Liou2, Eugene Chan3, Thomas Duke4, and Edward C. Cox5
1Department of Physics, Princeton University, Princeton, New Jersey 08544
2Institute of Atomic and Molecular Sciences, Academia Sinica and Department of Physics, National Taiwan University, Taipei, Taiwan
3U.S. Genomics, Woburn, Massachusetts 01801
4Cavendish Laboratory, Cambridge University, Cambridge, CB3 0HE, United Kingdom
5Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544

Received 13 March 2000; published in the issue dated 12 February 2001

We have fabricated using electron beam nanolithography a fixed slit near-field optical scanning device which uses near-field fluorimetry to achieve 200 nm spatial resolution of objects moving over the slits. We explore the basic physics of operating narrow slits in the waveguide cutoff mode and present data from the passage of extended double-stranded DNA molecules passing over the slits as a first example of how this device can be used to do ultrahigh spatial resolution mapping of long polymers.

© 2001 The American Physical Society

URL:
http://link.aps.org/doi/10.1103/PhysRevLett.86.1378
DOI:
10.1103/PhysRevLett.86.1378
PACS:
87.15.-v
 
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