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APS » Journals » Phys. Rev. Lett. » Volume 87 » Issue 24
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Phys. Rev. Lett. 87, 248102 (2001) [4 pages]

Picometer-Scale Dynamical X-Ray Imaging of Single DNA Molecules

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Yuji C. Sasaki1,2,*, Yasuaki Okumura3, Shinichi Adachi4, Hitoshi Suda5, Yoshio Taniguchi3, and Naoto Yagi1
1Biomedical Group, Japan Synchrotron Radiation Research Institute, SPring-8, Mikazuki, Hyogo 679-5198, Japan
2Unit Process and Combined Circuit, PRESTO, Japan Science and Technology Corporation (JST), Osaka 560-0082, Japan
3Faculty of Textile Science & Technology, Shinshu University, Ueda, Nagano 386-8567, Japan
4The Institute of Physical and Chemical Research (RIKEN), Mikazuki, Hyogo 679-5143, Japan
5Department of Biological Science and Technology, Tokai University, Numazu, Shizuoka 410-0321, Japan

Received 20 February 2001; published 26 November 2001

Time-resolved dynamical x-ray imaging of individual DNA molecules with picometer-scale precision is demonstrated for the first time. Diffracted x-ray tracking (DXT), a single-molecule experiment with x rays, monitors the rotating motions, rather than the translational motions, of a labeled nanocrystal. DXT can obtain information about the dynamics of single molecules through a quantitative analysis, since the signals from DXT are independent of the chemical conditions.

© 2001 The American Physical Society

URL:
http://link.aps.org/doi/10.1103/PhysRevLett.87.248102
DOI:
10.1103/PhysRevLett.87.248102
PACS:
87.64.-t, 07.85.Qe, 61.10.-i

*To whom all correspondence and requests for materials should be addressed. Email address: ycsasaki@spring8.or.jp

 
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