Phys. Rev. Lett. 88, 198102 (2002) [4 pages]

Experimental Control of Cardiac Muscle Alternans

Abstract

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G. Martin Hall^* and Daniel J. Gauthier^†
Department of Physics, Department of Biomedical Engineering and Center for Nonlinear and Complex Systems, Duke University, Box 90305, Durham, North Carolina 27708

Received 26 July 2001; published 30 April 2002

We demonstrate that alternans in small pieces of in vitro paced bullfrog (Rana Catesbeiana) myocardium can be suppressed by making minute adjustments to the pacing period in response to real time measurements of the action potential duration. Control is possible over a large range of physiological conditions over many animals and the self-referencing control protocol can automatically adjust to changes in the pacing interval. Our results suggest the feasibility of developing low-energy methods for maintaining normal cardiac function.

URL:

http://link.aps.org/doi/10.1103/PhysRevLett.88.198102

DOI:

10.1103/PhysRevLett.88.198102

PACS:

87.15.Aa, 05.45.-a, 87.10.+e

^*Present address: Corvis Corp., 7015 Albert Einstein Drive, Columbia, MD 21046-9400.

^†Corresponding author. Email address: gauthier@phy.duke.edu.

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Phys. Rev. Lett. 88, 198102 (2002) [4 pages]

Experimental Control of Cardiac Muscle Alternans