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APS » Journals » Phys. Rev. Lett. » Volume 90 » Issue 11
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Phys. Rev. Lett. 90, 118102 (2003) [4 pages]

DNA Fuel for Free-Running Nanomachines

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A. J. Turberfield* and J. C. Mitchell
University of Oxford, Department of Physics, Clarendon Laboratory, Parks Road, Oxford OX1 3PU, United Kingdom

B. Yurke, A. P. Mills, Jr.†, M. I. Blakey, and F. C. Simmel‡
Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, New Jersey 07974

Received 7 August 2002; published 18 March 2003

We describe kinetic control of DNA hybridization: loop complexes are used to inhibit the hybridization of complementary oligonucleotides; rationally designed DNA catalysts are shown to be effective in promoting their hybridization. This is the basis of a strategy for using DNA as a fuel to drive free-running artificial molecular machines.

© 2003 The American Physical Society

URL:
http://link.aps.org/doi/10.1103/PhysRevLett.90.118102
DOI:
10.1103/PhysRevLett.90.118102
PACS:
87.15.He, 81.07.Nb, 81.16.Dn, 81.16.Hc

*Electronic address: A.Turberfield@physics.ox.ac.uk

†Present address: Department of Physics, University of California Riverside, CA 92521.

‡Present address: Ludwig-Maximilians-Universität München, Sektion Physik, Geschwister-Scholl-Platz 1, 80539 München, Germany.

 
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