Phys. Rev. Lett. 90, 168101 (2003) [4 pages]Formation of Electrically Active Clusterized Neural NetworksReceived 1 July 2002; published 21 April 2003 Ordinarily, in vitro neurons self-organize into homogeneous networks of single neurons linked by dendrites and axons. We show that under special conditions they can also self-organize into neuronal clusters, which are linked by bundles of axons. Multielectrode array measurement reveals that the clusterized networks are also electrically active and exhibit synchronized bursting events similar to those observed in the homogeneous networks. From time-lapse recording, we deduced the features required for the neuronal clusterized versus homogeneous self-organization and developed a simple model for testing their validity. © 2003 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.90.168101
DOI:
10.1103/PhysRevLett.90.168101
PACS:
87.19.La, 05.65.+b, 84.35.+i
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