Phys. Rev. Lett. 91, 158103 (2003) [4 pages]Exponential DNA Replication by Laminar Convection
See accompanying Physics Focus It is shown that laminar thermal convection can drive a chain reaction of DNA replication. The convection is triggered by a constant horizontal temperature gradient, moving molecules along stationary paths between hot and cold regions. This implements the temperature cycling for the classical polymerase chain reaction (PCR). The amplification is shown to be exponential and reaches 100 000-fold gains within 25 min. Besides direct applications, the mechanism might have implications for the molecular evolution of life. © 2003 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.91.158103
DOI:
10.1103/PhysRevLett.91.158103
PACS:
87.15.Rn, 82.39.Rt, 87.14.Gg, 89.75.Fb
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