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Phys. Rev. Lett. 91, 265506 (2003) [4 pages]

Behavior of Complex Knots in Single DNA Molecules

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Xiaoyan R. Bao, Heun Jin Lee, and Stephen R. Quake
Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA

See Also: Erratum

Received 1 August 2003; published 31 December 2003

See accompanying Physics Focus

We used optical tweezers to tie individual DNA molecules in knots. Although these knots become highly localized under tension, they remain surprisingly mobile and undergo thermal diffusion with classical random walk statistics. The diffusion constants of knots with different complexities correlate with theoretical calculations of knot sizes. We show that this correlation can be explained by a simple hydrodynamical model of “self-reptation” of the knot along a polymer.

© 2003 The American Physical Society

URL:
http://link.aps.org/doi/10.1103/PhysRevLett.91.265506
DOI:
10.1103/PhysRevLett.91.265506
PACS:
61.41.+e, 02.10.Kn, 87.15.–v

See Also

Erratum: Xiaoyan R. Bao, Heun Jin Lee, and Stephen R. Quake, Erratum: Behavior of Complex Knots in Single DNA Molecules [Phys. Rev. Lett. 91, 265506 (2003)], Phys. Rev. Lett. 95, 199901 (2005).