Phys. Rev. Lett. 94, 196101 (2005) [4 pages]

Statics and Dynamics of Single DNA Molecules Confined in Nanochannels

Abstract

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Walter Reisner¹, Keith J. Morton², Robert Riehn¹, Yan Mei Wang¹, Zhaoning Yu², Michael Rosen³, James C. Sturm², Stephen Y. Chou², Erwin Frey⁴, and Robert H. Austin^1,*
¹Physics Department, Princeton University, Princeton, New Jersey 08544, USA
²Department of Electrical Engineering, Princeton University, Princeton, New Jersey 08544, USA
³Physics Department, Stanford University, Stanford, California 94309, USA
⁴Arnold Sommerfeld Center, Physics Department, Ludwig-Maximilians-Universität München, Theresienstraße 37, D-80333 München, Germany

Received 15 November 2004; published 16 May 2005

The successful design of nanofluidic devices for the manipulation of biopolymers requires an understanding of how the predictions of soft condensed matter physics scale with device dimensions. Here we present measurements of DNA extended in nanochannels and show that below a critical width roughly twice the persistence length there is a crossover in the polymer physics.

URL:

http://link.aps.org/doi/10.1103/PhysRevLett.94.196101

DOI:

10.1103/PhysRevLett.94.196101

PACS:

81.16.Nd, 82.35.Lr, 82.39.Pj

^*Electronic address: austin@princeton.edu

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Phys. Rev. Lett. 94, 196101 (2005) [4 pages]

Statics and Dynamics of Single DNA Molecules Confined in Nanochannels