Phys. Rev. Lett. 94, 028103 (2005) [4 pages]

Control of Traveling Waves in the Mammalian Cortex

Abstract

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Kristen A. Richardson^1,2, Steven J. Schiff^1,3,4, and Bruce J. Gluckman^1,2,3,*
¹Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia 22030, USA
²Department of Physics and Astronomy, George Mason University, Fairfax, Virginia 22030, USA
³Program in Neuroscience, George Mason University, Fairfax, Virginia 22030, USA
⁴Department of Psychology, George Mason University, Fairfax, Virginia 22030, USA

Received 29 June 2004; published 19 January 2005

We experimentally confirmed predictions that modulation of the neuronal threshold with electrical fields can speed up, slow down, and even block traveling waves in neocortical slices. The predictions are based on a Wilson-Cowan–type integro-differential equation model of propagating neocortical activity. Wave propagation could be modified quickly and reversibly within targeted regions of the network. To the best of our knowledge, this is the first example of direct modulation of the threshold to control wave propagation in a neural system.

URL:

http://link.aps.org/doi/10.1103/PhysRevLett.94.028103

DOI:

10.1103/PhysRevLett.94.028103

PACS:

87.17.Nn, 02.60.Nm, 82.40.Ck, 87.50.Rr

^*Electronic address: bgluckma@gmu.edu

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Phys. Rev. Lett. 94, 028103 (2005) [4 pages]

Control of Traveling Waves in the Mammalian Cortex