Phys. Rev. Lett. 95, 118102 (2005) [4 pages]

Effective Long-Range Attraction between Protein Molecules in Solutions Studied by Small Angle Neutron Scattering

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Yun Liu¹, Emiliano Fratini², Piero Baglioni^1,2, Wei-Ren Chen¹, and Sow-Hsin Chen^1,*
¹Department of Nuclear Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
²Department of Chemistry and CSGI, University of Florence, via della Lastruccia 3, 50019 Florence, Italy

Received 8 February 2005; published 8 September 2005

Small angle neutron scattering intensity distributions taken from cytochrome C and lysozyme protein solutions show a rising intensity at a very small wave vector Q, which can be interpreted in terms of the presence of a weak long-range attraction between protein molecules. This interaction has a range several times that of the diameter of the protein molecule, much greater than the range of the screened electrostatic repulsion. We show evidence that this long-range attraction is closely related to the type of anion present and ion concentration in the solution.

URL:

http://link.aps.org/doi/10.1103/PhysRevLett.95.118102

DOI:

10.1103/PhysRevLett.95.118102

PACS:

87.14.Ee, 61.12.Ex, 82.35.Rs

^*To whom correspondence should be addressed.

Email address: sowhsin@mit.edu

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Phys. Rev. Lett. 95, 118102 (2005) [4 pages]

Effective Long-Range Attraction between Protein Molecules in Solutions Studied by Small Angle Neutron Scattering

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