Phys. Rev. Lett. 95, 228101 (2005) [4 pages]Compaction of Single-Chain DNA by Histone-Inspired NanoparticlesReceived 6 May 2005; published 21 November 2005 We elaborated a versatile experimental model of chromatin which consists of a single chain of long duplex DNA that interacts with well-defined cationic nanoparticles of various sizes. We found that the DNA compaction by nanoparticles is stepwise and progressive at the single-chain level. It is controlled by the ability of DNA to wrap nanoparticles, which is more efficient for larger particles and, similar to DNA-histone interaction, is optimal at a physiological salt concentration. © 2005 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.95.228101
DOI:
10.1103/PhysRevLett.95.228101
PACS:
87.15.−v, 61.25.Hq, 81.07.−b, 87.14.Gg
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