Phys. Rev. Lett. 98, 106101 (2007) [4 pages]Direct Imaging of Lipid-Ion Network Formation under Physiological Conditions by Frequency Modulation Atomic Force MicroscopyReceived 11 December 2006; published 5 March 2007 Various metal cations in physiological solutions interact with lipid headgroups in biological membranes, having an impact on their structure and stability, yet little is known about the molecular-scale dynamics of the lipid-ion interactions. Here we directly investigate the extensive lipid-ion interaction networks and their transient formation between headgroups in a dipalmitoylphosphatidylcholine bilayer under physiological conditions. The spatial distribution of ion occupancy is imaged in real space by frequency modulation atomic force microscopy with sub-Ångstrom resolution. © 2007 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.98.106101
DOI:
10.1103/PhysRevLett.98.106101
PACS:
68.37.Ps, 68.55.−a, 81.07.−b, 87.14.Cc
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