Phys. Rev. Lett. 98, 058105 (2007) [4 pages]Structural Polymorphism of the Actin-Espin System: A Prototypical System of Filaments and Linkers in StereociliaReceived 30 June 2006; published 1 February 2007 We examine the interaction between cytoskeletal F-actin and espin 3A, a prototypical actin bundling protein found in sensory cell microvilli, including ear cell stereocilia. Espin induces twist distortions in F-actin as well as facilitates bundle formation. Mutations in one of the two F-actin binding sites of espin, which have been implicated in deafness, can tune espin-actin interactions and radically transform the system’s phase behavior. These results are compared to recent theoretical work on the general phase behavior linker-rod systems. © 2007 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.98.058105
DOI:
10.1103/PhysRevLett.98.058105
PACS:
87.16.Ka, 61.10.Eq, 61.30.Eb, 61.30.St
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