Phys. Rev. Lett. 98, 098105 (2007) [4 pages]How Xenopus Laevis Replicates DNA Reliably even though Its Origins of Replication are Located and Initiated StochasticallyReceived 4 November 2006; published 27 February 2007 DNA replication in Xenopus laevis is extremely reliable, failing to complete before cell division no more than once in 10 000 times; yet replication origin sites are located and initiated stochastically. Using a model based on 1D theories of nucleation and growth and using concepts from extreme-value statistics, we derive the distribution of replication times given a particular initiation function. We show that the experimentally observed initiation strategy for Xenopus laevis meets the reliability constraint and is close to the one that requires the fewest resources of a cell. © 2007 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.98.098105
DOI:
10.1103/PhysRevLett.98.098105
PACS:
87.15.Aa, 87.14.Gg, 87.15.Ya, 87.17.Ee
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