Phys. Rev. Lett. 99, 158104 (2007) [4 pages]Plasma and Cavitation Dynamics during Pulsed Laser Microsurgery in vivoReceived 21 May 2007; published 10 October 2007 We compare the plasma and cavitation dynamics underlying pulsed laser microsurgery in water and in fruit fly embryos (in vivo)—specifically for nanosecond pulses at 355 and 532 nm. We find two key differences. First, the plasma-formation thresholds are lower in vivo —especially at 355 nm—due to the presence of endogenous chromophores that serve as additional sources for plasma seed electrons. Second, the biological matrix constrains the growth of laser-induced cavitation bubbles. Both effects reduce the disrupted region in vivo when compared to extrapolations from measurements in water. © 2007 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevLett.99.158104
DOI:
10.1103/PhysRevLett.99.158104
PACS:
87.80.−y, 47.55.dp, 52.38.Mf, 52.50.Jm
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